Drug metabolism handbook : concepts and applications

Drug metabolism handbook : concepts and applications /

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Bibliographic Details
Other Authors: Nassar, Ala F., Hollenberg, Paul F., Scatina, JoAnn
Format: Book
Language:English
Published: Hoboken, N.J. : Wiley, [2009]
Subjects:
Drugs > Metabolism > Handbooks, manuals, etc.
Medication.
Therapies.
Drugs > Metabolism.
Drugs.
Handbooks and manuals.
Online Access:View Table of contents only
Table of Contents:
  • Pt. 1: Introduction: 1. Historical perspective/Roberta S. King
  • 2. Factors affecting metabolism/Roberta S. King
  • 3. Biotransformations in drug metabolism/Roberta s. King
  • 4. In Vivo metabolite kinetics/Zheng Yang
  • 5. Pharmacogenetics and pharmacogenomics/Lilian G. Yengi
  • 6. Introduction to drug transporters/Louis Leung and Aram Oganesian
  • Pt. 2. Technologies for In Vitro and In Vivo studies: 7. Automated drug screening for ADMET properties/Melvin Reichman and Helen Gill
  • 8. Mass spectrometry/Thomas R. Sharp
  • 9. Approaches to performing metabolite elucidation: one key to success in drug discovery and development/Ala F. Nassar
  • 10. Structural modifications of drug candidates: how useful are they in improving metabolic stability of new drugs? Pt. 1. Enhancing metabolic stability/Alaf F. Nassar
  • 11. Structural modifications of drug candidates: how useful are they in improving PK parameters of new drugs? Pt. 2. Drug design strategies/Alaf F. Nassar
  • 12. Minimizing the potential for dfrug bioactivation of drug candidates to success in clinical development/Alaf F. Nassar
  • 13. Screening for reactive metabolites using genotoxicity arrays and enzyme/DNA biocolloids/James F. Rusling, ... [et al.]
  • Pt. 3. Drug Interactions: 14. Enzyme inhibition/Paul F. Hollenberg
  • 15. Evaluating and predicting human cytochrome P450 enzyme induction/Michael Sinz, ... [et al.]
  • 16. An introduction to metabolic reaction phenotyping/Carl D. Davis and A. David Rodrigues
  • 17. Nuclear receptor-mediated gene regulation in drug metabolism/Hongbing Wang and Wen Xie
  • 18. Charaterization of Cytochrome P450 mechanism-based inhibition/Dan Rock and Larry C. Wienkers
  • 19. Clinical drug-drug interactions/Sujal V. Deshmukh
  • 20. Pharmaceutical excipients in drug-drug interaction/Chuan Chen and Abu J.M. Sadeque
  • Pt. 4. Toxicity: 21. The role of drug metabolism in toxicity/Carl D. Davis and Umesh M. Hanumegowda
  • 22. Allergic reactions to drugs/Mark P. Grillo
  • 23. Chemical mechanisms in toxicology/Mark P. Grillo
  • 24. Mechanisms of reproductive toxicity/Aileen F. Keating and Patricia B. Hoyer
  • 25. An introduction to toxicogenomics/Aaron L. Vollrath and Christopher A. Bradfield
  • 26. Role of bioactivation reactions in chemically induced nephrotoxicity/Laerence H. Lash
  • Pt. 5. Regulatory perspectives: 27. Drug metabolism in regulatory guidances, clinical trials, and product labeling/Mark N. Milton.

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