Pain genetics : basic to translational science /
Saved in:
| Corporate Author: | |
|---|---|
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Ames, Iowa :
Wiley Blackwell,
2014.
|
| Subjects: | |
| Online Access: | Connect to this title online (unlimited simultaneous users allowed; 325 uses per year) |
Table of Contents:
- Machine generated contents note: 1. How Do Pain Genes Affect Pain Experience? / Marshall Devor
- Introduction
- Heritability of Pain: Historical Roots
- Why is Pain Genetics Interesting and Potentially Useful?
- What Are Pain Genes?
- How Do Pain Genes Affect Pain Experience?
- Disease Susceptibility Genes Versus Pain Susceptibility Genes
- Perspective
- Acknowledgments
- 2. Conservation of Pain Genes Across Evolution / G. Greg Neely
- Introduction
- Anatomical Organization of Nociception Apparatus in Mammals and Drosophila
- Acute Heat Pain in Mammals
- Acute Heat Nociception in Drosophila
- Mechanical Pain in Mammals
- Mechanical Nociception in Drosophila
- Chemical Nociception in Mammals
- Chemical Nociception in Drosophila
- Inflammatory Pain in Mammals
- Persistent Pain in Drosophila
- Neuropathic Pain in Mammals
- Structural Reorganizations of Nerve Fibers in Neuropathic Pain
- Mammalian Neuropathic Pain Genes That Are Conserved in Drosophila
- Long-Term Potentiation and Long-Term Depression in Neuropathic Pain in Mammals
- Neuropathic Pain in Drosophila
- Conclusions
- 3. Defining Human Pain Phenotypes for Genetic Association Studies / Christopher Sivert Nielsen
- Introduction
- What is a Pain Phenotype?
- Pain Scaling
- Heritability
- Genotype--Phenotype Matching
- Reliability and Temporal Stability
- Clinical Phenotypes
- Designing Clinical Pain Genetic Studies
- Heritability of Specific Clinical Pain Conditions
- Experimental Phenotypes
- Heritability of Experimental Phenotypes
- Extended Phenotypes
- Practical Concerns
- Conclusions
- Conflict of Interest Statement
- 4. Genetic Contributions to Pain and Analgesia: Interactions with Sex and Stress / Jeffrey S. Mogil
- Introduction
- Brief Overview of Sex and Gender Differences in Pain and Analgesia
- Brief Overview of Stress and Pain/Analgesia
- Sex X Gene Interactions in Pain and Analgesia
- Summary
- 5. Abnormal Pain Conditions in Humans Related to Genetic Mutations / Christopher Geoffrey Woods
- Introduction to SCN9A, NTRK1, and NGF and the Roles They Play in Pain
- Introduction to SCN9A and Its Omnipotent Role in Pain Sensing
- Introduction to NTRK1 and Its Role in Development and Function in the Pain and Sympathetic Nervous Systems
- Introduction to NGF, the First Nerve Growth Factor to Be Found and Studied
- 6. Alternative Pre-mRNA Splicing of Mu Opioid Receptor Gene: Molecular Mechanisms Underlying the Complex Actions of Mu Opioids / Ying-Xian Pan
- Introduction
- Evolution of OPRM 1 Gene
- OPRM 1 Gene: Chromosomal Location and Gene Structure
- Alternative Promoters
- Alternative Pre-mRNA Splicing of the OPRM 1 Gene
- Expression and Function of the OPRM 1 Splice Variants
- Conclusion
- 7. Discovering Multilocus Associations with Complex Pain Phenotypes / Dmitri Zaykin
- Introduction
- Approaches Based on Testing Individual Genetic Variants Within a Region
- Approaches That Combine Association Signals Across Genetic Variants
- Methods for Testing Joint Effects of Multiple Genetic Variants
- Multilocus Analysis of Mu Opioid Receptor Haplotypes
- Two-Stage Multilocus Association Analysis: Collapsing SNPs with Adjustment for Effect Directions
- Two-Stage Approach: Simulations
- Two-Stage Approach: Results
- Discussion
- Acknowledgments
- 8. Overlapping Phenotypes: Genetic Contribution to Nausea and Pain / Charles C. Horn
- Introduction
- What is the Functional Role of Nausea and Vomiting?
- Pain Syndromes with Significant Nausea
- Neuropharmacology of Nausea and Emesis
- Emetic and Antiemetic Action of Opioids
- Preclinical Studies of Nausea and Vomiting
- Heritability of Nausea and Vomiting Phenotypes
- Human Genetic Sequence Variants Associated with Nausea and Vomiting
- Summary and Future Directions
- 9. Counterpart to Pain: Itch / Sarah E. Ross
- Introduction
- Why Do We Scratch?
- Basics of Itch
- So How is Itch Coded?
- Measuring Itch in Mice
- Genetic Models of Itch
- Key Role for the Skin in Itch
- Shift in the Balance of Pain and Itch
- Genetic Variation and Itch in Humans
- Challenges for the Future
- Acknowledgments
- 10. Translating Genetic Knowledge into Clinical Practice for Musculoskeletal Pain Conditions / William Maixner
- Introduction
- Results of Human Association Studies
- Gene Sequencing
- Development of New Therapeutics
- Understanding of Interactions
- In Summary
- 11. Human Chronic Pain Phenome: Mapping Nongenetic Modifiers of the Heritable Risk / Joel Katz
- Current Crisis in Pain Medicine
- Importance of Estimating Risk of Chronic Neuropathic Pain (CNP)
- Modification of the Heritable Risk for CNP
- Natural History of CNP
- Modification of Heritable Risk for CNP In Utero
- Modifications of the Heritable Risk for CNP Across Generations
- Postnatal Modifications of the Heritable Risk for CNP
- Modifications of the Heritable Risk for CNP by Childhood Adverse Experiences
- Modifications of the Heritable Risk for CNP by Prior Chronic Pain Epochs
- Modification of the Heritable Risk for CNP by Certain Personality Traits
- Modification of the Heritable Risk for CNP by Social Factors
- Modification of the Heritable Risk for CNP by Diet, Medications, Smoking, and Alcohol Intake Consumed Preoperatively
- Modification of the Heritable Risk for CNP by Climate
- Modification of the Heritable Risk for CNP by Lifestyle
- Modifications of the Heritable Risk for Chronic Pain by Other Diseases
- Modifications of the Heritable Risk for CNP by Nongenetic Factors Occurring Just Prior and During the Inciting Event
- Summary.