TNF Receptor Associated Factors (TRAFs)

TNF Receptor Associated Factors (TRAFs) /

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It has been established that TNF receptor associated factors (TRAFs) are critical signaling mediators for not only the TNF receptor superfamily, but also the interleukin-1 receptor/Toll-like receptor superfamily and the T-cell receptors. They play important roles in mammalian biology including embry...

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Bibliographic Details
Other Authors: Wu, Hao, Dr (Editor)
Format: Electronic eBook
Language:English
Published: New York, NY : Springer New York, 2007.
Series:Advances in experimental medicine and biology ; 597.
Subjects:
Life sciences.
Computer security.
Cytology.
Developmental biology.
Life Sciences.
Cell Biology.
Developmental Biology.
Systems and Data Security.
Online Access:Connect to this title online
Table of Contents:
  • Phylogeny of the TRAF/MATH Domain
  • TRAF1 and Its Biological Functions
  • Physiological Roles and Mechanisms of Signaling by TRAF2 and TRAF5
  • TRAF3 and Its Biological Function
  • TRAF4, the Unique Family Member
  • Characteristics and Biological Functions of TRAF6
  • Ubiquitination and TRAF signaling
  • Structural Revelations of TRAF2 Function in TNF Receptor Signaling Pathway
  • Protein-Protein Interactions in TRAF3
  • Molecular Basis for the Unique Specificity of TRAF6
  • TRAF Proteins in CD40 Signaling
  • TRAFs in RANK Signaling
  • The LT?R Signaling Pathway
  • LMP1 TRAFficking Activates Growth and Survival pathways
  • Targeting TRAFs for Therapeutic Intervention.

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