Genome Stability and Human Diseases /
Since the establishment of the DNA structure researchers have been highly interested in the molecular basis of the inheritance of genes and of genetic disorders. Scientific investigations of the last two decades have shown that, in addition to oncogenic viruses and signalling pathways alterations, g...
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| Other Authors: | |
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
Dordrecht :
Springer Netherlands,
2010.
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| Series: | Sub-cellular biochemistry ;
50. |
| Subjects: | |
| Online Access: | Connect to this title online |
Table of Contents:
- Coming Full Circle: Cyclin-Dependent Kinases as Anti-cancer Drug Targets
- Core and Linker Histone Modifications Involved in the DNA Damage Response
- Chromatin Assembly and Signalling the End of DNA Repair Requires Acetylation of Histone H3 on Lysine 56
- Structure and Function of Histone H2AX
- The Initiation Step of Eukaryotic DNA Replication
- Non-coding RNAs: New Players in the Field of Eukaryotic DNA Replication
- Function of TopBP1 in Genome Stability
- Eukaryotic Single-Stranded DNA Binding Proteins: Central Factors in Genome Stability
- DNA Polymerases and Mutagenesis in Human Cancers
- DNA Polymerase ?, a Key Protein in Translesion Synthesis in Human Cells
- The Mitochondrial DNA Polymerase in Health and Disease
- Centromeres: Assembling and Propagating Epigenetic Function
- Nucleotide Excision Repair in Higher Eukaryotes: Mechanism of Primary Damage Recognition in Global Genome Repair
- Nonhomologous DNA End Joining (NHEJ) and Chromosomal Translocations in Humans
- Fluorescence-Based Quantification of Pathway-Specific DNA Double-Strand Break Repair Activities: A Powerful Method for the Analysis of Genome Destabilizing Mechanisms
- Apoptosis: A Way to Maintain Healthy Individuals
- The Use of Transgenic Mice in Cancer and Genome Stability Research.