Serotonin and Anxiety : Neuroanatomical, Pharmacological, and Functional Aspects /
Anxiety disorders have long been a research subject for scientists in different areas of inquiry, and the particular role of serotonin – the neurotransmitter which has probably most captured the imagination of laymen and academics alike – is as elusive as the clinical aspects of serotonergic medicat...
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| Format: | Electronic eBook |
| Language: | English |
| Published: |
New York, NY :
Springer New York : Imprint: Springer,
2012.
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| Series: | SpringerBriefs in neuroscience.
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| Subjects: | |
| Online Access: | Connect to this title online |
Table of Contents:
- Introduction and scope of the review
- Anxiety and risk assessment
- Fear/panic and the fight/flight/freeze system
- “Coping” styles, stress reactivity, and the active-passive continuum
- Serotonin in the nervous system of vertebrates
- Synthesis and metabolism of serotonin
- Transport of serotonin: SERT and uptake
- Serotonin receptors
- 5-HT1A receptors
- 5-HT1B receptors
- 5-HT2C receptors
- Nodal structures in anxiety-like and panic-like responses
- Nodal structures regulating anxiety: The behavioral inhibition system
- “Limbic” portions of the medial prefrontal cortex
- The extended amygdala
- The ventral hippocampus
- The lateral habenula
- Nodal structures regulating panic: The cerebral aversive system
- The central amygdala
- The medial hypothalamic defense system
- The mesopontine rostromedial tegmental nucleus
- The periaqueductal gray area
- Locus coeruleus
- The dual role hypothesis
- Destruction or blockade of DRN neurons is anxiolytic and panicogenic
- The defensive context for increased serotonin release
- Topographic organization of DRN. - The dorsal portion of the DRN is part of a mesocorticolimbic system involved in anxiety-like responses
- The caudal portion of the DRN is highly responsive to stress-related peptides
- The lateral wings of the DRN are involved in panic-like responses
- General conclusions.