Crumbling genome /
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| Main Author: | |
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| Corporate Author: | |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Hoboken, NJ :
John Wiley & Sons,
2017.
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| Subjects: | |
| Online Access: | Connect to this title online (unlimited simultaneous users allowed; 325 uses per year) |
Table of Contents:
- Machine generated contents note: 1.1. DNA is a Text
- 1.2. Genomes Small and Large
- 1.3. Genes and Intergenic Regions
- 1.4. Cells, Mitosis, and Meiosis
- 1.5. From Genotype to Phenotype
- Further Reading
- 2.1. Inheritance is Discrete
- 2.2. Populations are Genetically Variable
- 2.3. Loci and Genes
- 2.4. Effects of Alleles on Phenotypes
- 2.5. Mendelian Traits and Diseases
- Further Reading
- 3.1. Complex Inheritance of Phenotypes
- 3.2. Properties of a Complex Trait
- 3.3. Complex Traits in Populations
- 3.4. Effects of Heredity and Environment on Complex Traits
- 3.5. Polymorphic Loci Behind Complex Variation
- Further Reading
- 4.1. Phenomenon of Mutation
- 4.2. Kinds of Mutations
- 4.3. Spontaneous Mutation
- 4.4. Evolution of Mutation Rates
- 4.5. Artificial Mutagenesis and Antimutagenesis
- Further Reading
- 5.1. Fidelity of DNA Replication
- 5.2. Cleaning Up After the Replisome
- 5.3. Dealing with DNA Damages
- 5.4. Harms of Broken Maintenance
- 5.5. Mechanisms of Mutation
- Further Reading
- 6.1. Measuring Mutation Rates
- 6.2. Data on Mutation Rates
- 6.3. Guilty Older Men
- 6.4. Rates of Phenotypically Drastic Mutations
- 6.5. Mild Mutations and Mutational Pressures
- Further Reading
- 7.1. Vulnerable Adaptations and Their Evolutionary Origin
- 7.2. Two Basic Characteristics of Selection
- 7.3. Measuring Natural Selection
- 7.4. Selection at a Polymorphic Locus
- 7.5. Selection on a Quantitative Trait
- Further Reading
- 8.1. Selective Neutrality and Random Drift
- 8.2. Effective Population Size
- 8.3. Junk DNA Provides the Simplest Evidence for Evolution
- 8.4. Finding Functioning Genome Segments
- 8.5. Genomic Rate of Deleterious Mutations
- Further Reading
- 9.1. Middle Class Neighborhood for Drosophila
- 9.2. Selection Against Deleterious Alleles
- 9.3. Mutation-Selection Equilibrium
- 9.4. Inbreeding Depression
- 9.5. Dangerous Slightly Deleterious Alleles
- Further Reading
- 10.1. Phenotypic and Genotypic Imperfection
- 10.2. Five Evolutionary Causes of Imperfection
- 10.3. Weakly Perfect Human Genotypes and Phenotypes
- 10.4. Native, Novel, and Optimal Environments
- 10.5. Factors, Exacerbating Mutation Imperfection
- Further Reading
- 11.1. Properties of an Allele
- 11.2. Human Derived Alleles
- 11.3. Average Imperfection of a Genotype
- 11.4. Variation Among Genotypes
- 11.5. Selection in Modern Human Populations
- Further Reading
- 12.1. Qualitative Characteristics of Wellness
- 12.2. Quantitative Traits
- 12.3. Contributions of Heredity and Environment
- 12.4. Wellness-impairing Alleles
- 12.5. Genetic Architecture of Wellness
- Further Reading
- 13.1. Mutational Pressure on Diseases
- 13.2. Mutational Pressure on Quantitative Traits
- 13.3. Possible Increase of the Mutational Pressure
- 13.4. De Novo Mutations and Human Wellness
- 13.5. Optimistic and Pessimistic Scenarios
- Further Reading
- 14.1. Lessons from History
- 14.2. Modern Practices
- 14.3. Humanist Ethics and the Main Concern
- 14.4. Main Concern and Ethical Dilemmas
- 14.5. Role of Scientists
- Further Reading
- 15.1. Conditionally Beneficial or Unconditionally Deleterious?
- 15.2. Mutationless Utopia: What Could It Be?
- 15.3. Mutationless Utopia: Is It Ever Going to Happen?
- 15.4. What Can I Do Without Germline Genotype Modification?
- 15.5. Prognosis
- Further Reading.