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200526s2021 gw a ob 001 0 eng |
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|a 2020024179
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020 |
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|a 9783527817856
|q electronic book
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|a 3527817859
|q electronic book
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|a 9783527817863
|q electronic book
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|a 3527817867
|q electronic book
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020 |
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|a 9783527817887
|q electronic book
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|a 3527817883
|q electronic book
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|z 9783527345212
|q hardcover
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024 |
7 |
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|a 10.1002/9783527817856
|2 doi
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035 |
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|a (DLC)ebc6523041
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040 |
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|a NhCcYBP
|c NhCcYBP
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|a pcc
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4 |
|a QP620
|b .S84 2021
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0 |
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|a 572.8
|2 23
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100 |
1 |
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|a Sugimoto, N.
|q (Naoki),
|e author.
|
245 |
1 |
0 |
|a Chemistry and biology of non-canonical nucleic acids /
|c Naoki Sugimoto.
|
264 |
|
1 |
|a Weinheim, Germany :
|b Wiley-VCH,
|c [2021]
|
300 |
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|a 1 online resource ( xii, 276 pages) :
|b illustrations (some color)
|
336 |
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|a text
|b txt
|2 rdacontent
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337 |
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|a computer
|b n
|2 rdamedia
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338 |
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|a online resource
|b nc
|2 rdacarrier
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504 |
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|a Includes bibliographical references and index.
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505 |
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|a Machine generated contents note:
|g 1.
|t History For Canonical And Non-Canonical Structures Of Nucleic Acids --
|g 1.1.
|t Introduction --
|g 1.2.
|t History of Duplex --
|g 1.3.
|t Non-Watson--Crick Base Pair --
|g 1.4.
|t Nucleic Acid Structures Including Non-Watson--Crick Base Pairs --
|g 1.5.
|t Perspective of the Research for Non-canonical Nucleic Acid Structures --
|g 1.6.
|t Conclusion and Perspective --
|t References --
|g 2.
|t Structures Of Nucleic Acids Now --
|g 2.1.
|t Introduction --
|g 2.2.
|t Unusual Base Pairs in a Duplex --
|g 2.2.1.
|t Hoogsteen Base Pair --
|g 2.2.2.
|t Purine--Pyrimidine Mismatches --
|g 2.2.3.
|t Purine--Purine Mismatches --
|g 2.2.4.
|t Pyrimidine--Pyrimidine Mismatches --
|g 2.3.
|t Non-canonical Backbone Shapes in DNA Duplex --
|g 2.4.
|t Branched DNA with Junction --
|g 2.5.
|t Multi-stranded DNA Helices --
|g 2.6.
|t Structures in RNA --
|g 2.6.1.
|t Basic Structure Distinctions of RNA --
|g 2.6.2.
|t Elements in RNA Secondary Structures --
|g 2.6.2.1.
|t Hairpin Loop --
|g 2.6.2.2.
|t Bulge Loop --
|g 2.6.2.3.
|t Internal Loop --
|g 2.6.3.
|t Elements in Tertiary Interactions of RNA --
|g 2.6.3.1.
|t A-Minor Interactions --
|g 2.6.3.2.
|t Ribose Zipper --
|g 2.6.3.3.
|t T-Loop Motif --
|g 2.6.3.4.
|t Kissing-Loop Interaction --
|g 2.6.3.5.
|t GNRA Tetraloop Receptor Interaction --
|g 2.6.3.6.
|t Pseudoknot Crosslinking Distant Stem Regions --
|g 2.7.
|t Conclusion --
|t References --
|g 3.
|t Stability Of Non-Canonical Nucleic Acids --
|g 3.1.
|t Introduction --
|g 3.2.
|t Factors Influencing Stabilities of the Canonical Duplexes --
|g 3.2.1.
|t Hydrogen Bond Formations --
|g 3.2.2.
|t Stacking Interactions --
|g 3.2.3.
|t Conformational Entropy --
|g 3.3.
|t Thermodynamic Analysis for the Formation of Duplex --
|g 3.4.
|t Factors Influencing Stabilities of the Non-canonical Nucleic Acids --
|g 3.4.1.
|t Factors Influencing Stability of Triplexes --
|g 3.4.2.
|t Factors Influencing Stability of Quadruplex --
|g 3.4.2.1.
|t G-Quadruplexes --
|g 3.4.2.2.
|t i-Motif --
|g 3.5.
|t Thermodynamic Analysis for the Non-canonical Nucleic Acids --
|g 3.5.1.
|t Thermodynamic Analysis for the Intramolecular Triplex and Tetraplex --
|g 3.5.2.
|t Thermodynamic Analysis for the Intermolecular Triplex --
|g 3.5.3.
|t Thermodynamic Analysis for the Tetraplex --
|g 3.6.
|t Conclusion --
|t References --
|g 4.
|t Physicochemical Properties Of Non-Canonical Nucleic Acids --
|g 4.1.
|t Introduction --
|g 4.2.
|t Spectroscopic Properties of Non-canonical Nucleic Acids --
|g 4.2.1.
|t Effect of Non-canonical Structure on UV Absorption --
|g 4.2.2.
|t Circular Dichroism of Non-canonical Nucleic Acids --
|g 4.2.3.
|t NMR Spectroscopy --
|g 4.2.4.
|t Other Spectroscopic Characteristics of Non-canonical Nucleic Acids --
|g 4.3.
|t Chemical Interactions on Non-canonical Nucleic Acids --
|g 4.3.1.
|t Hydration --
|g 4.3.2.
|t Cation Binding --
|g 4.3.3.
|t pH Effect --
|g 4.3.4.
|t Chemical Modification --
|g 4.4.
|t Chemical Platform on the Non-canonical Structures --
|g 4.4.1.
|t Specificity of a Ligand to Non-canonical Structures --
|g 4.4.2.
|t Fluorescence Platform of Non-canonical Structures --
|g 4.4.3.
|t Interface Between Proteins and Nucleic Acids --
|g 4.5.
|t Physicochemical Property of Non-canonical Nucleic Acids in Cell --
|g 4.5.1.
|t Molecular Crowding Condition that Reflects Cellular Environments --
|g 4.5.2.
|t Effects of Crowding Reagents on Non-canonical Nucleic Acid Structures --
|g 4.5.3.
|t Quantification of Physical Properties of Non-canonical Structures in Crowding Condition --
|g 4.5.4.
|t Non-canonical Structures Under Mimicking Organelle Environment --
|g 4.5.5.
|t Insight for the Formation of Non-canonical Nucleic Acids in Cells --
|g 4.6.
|t Conclusion --
|t References --
|g 5.
|t Telomere --
|g 5.1.
|t Introduction --
|g 5.2.
|t Structural Properties of Telomere --
|g 5.2.1.
|t Structures of Telomere --
|g 5.2.2.
|t Structural Properties of Human Telomeric G4s --
|g 5.2.3.
|t Structure of Repeats of Human Telomeric G4s --
|g 5.3.
|t Biological Relevance of Telomere G4 --
|g 5.3.1.
|t Telomerase Activity --
|g 5.3.2.
|t Telomerase Repeated Amplification Protocol (TRAP) Assay --
|g 5.3.3.
|t Alternative Lengthening of Telomere (ALT) Mechanism --
|g 5.4.
|t Other Non-canonical Structures Related to Telomere Region --
|g 5.4.1.
|t Telomere i-Motif --
|g 5.4.2.
|t Telomere RNA --
|g 5.5.
|t Conclusion --
|t References --
|g 6.
|t Transcription --
|g 6.1.
|t Introduction --
|g 6.2.
|t Transcription Process --
|g 6.2.1.
|t Transcription Initiation --
|g 6.2.2.
|t Transcription Elongation --
|g 6.2.3.
|t Transcription Termination --
|g 6.3.
|t Transcription Process Perturbed by Certain Sequences of DNA and RNA --
|g 6.4.
|t Transcription Process Perturbed by Non-canonical Structures of DNA and RNA --
|g 6.5.
|t Conclusion --
|t References --
|g 7.
|t Translation --
|g 7.1.
|t Introduction --
|g 7.2.
|t RNAs Involved in Translation Machinery --
|g 7.3.
|t General Process of Translation --
|g 7.3.1.
|t Translation Initiation --
|g 7.3.2.
|t Translation Elongation --
|g 7.3.3.
|t Translation Termination --
|g 7.4.
|t RNA Structures Affecting Translation Reaction --
|g 7.4.1.
|t Modulation of Translation Initiation in Prokaryotes --
|g 7.4.2.
|t Modulation of Translation Initiation in Eukaryotes --
|g 7.4.3.
|t RNA Structures Affecting Translation Elongation --
|g 7.4.4.
|t RNA Structures Affecting Translation Termination --
|g 7.5.
|t Conclusion --
|t References --
|g 8.
|t Replication --
|g 8.1.
|t Introduction --
|g 8.2.
|t Replication Machineries --
|g 8.3.
|t Replication Initiation --
|g 8.3.1.
|t Mechanism of Activation of Replication Origins --
|g 8.3.2.
|t Activation Control of Origins by G4s --
|g 8.3.3.
|t Control of Timing of Replication Initiation by G4s --
|g 8.4.
|t DNA Strand Elongation --
|g 8.4.1.
|t Mechanism of DNA Strand Elongation --
|g 8.4.2.
|t Impact of G4 and i-Motif Formations on DNA Strand Synthesis --
|g 8.4.3.
|t Relationship Between G4 and Epigenetic Modification --
|g 8.4.4.
|t Expansion and Contraction of Replicating Strand Induced by Hairpin Structures --
|g 8.5.
|t Termination of Replication --
|g 8.6.
|t Chemistry of the Replication and Its Regulation --
|g 8.6.1.
|t Cellular Environments --
|g 8.6.2.
|t Control of Replication by Chemical Compounds --
|g 8.7.
|t Conclusion --
|t References --
|g 9.
|t Helicase --
|g 9.1.
|t Introduction --
|g 9.2.
|t Function and Structure of Helicases --
|g 9.3.
|t Unwinding of Non-canonical DNA Structures by Helicases --
|g 9.4.
|t G4 Helicases in Gene Expressions --
|g 9.5.
|t G4 Helicases in Replication --
|g 9.6.
|t G4 Helicases in Telomere Maintenance --
|g 9.7.
|t Relation to Diseases by Loss of G4 Helicases --
|g 9.8.
|t Insight into Specific Properties of Activities of G4 Helicase Under Cellular Conditions --
|g 9.9.
|t Conclusion --
|t References --
|g 10.
|t Dynamic Regulation Of Biosystems By Nucleic Acids With Non-Canonical Structures --
|g 10.1.
|t Introduction --
|g 10.2.
|t Time Scale of Biological Reactions --
|g 10.2.1.
|t Cell Cycle --
|g 10.2.2.
|t Central Dogma --
|g 10.2.3.
|t Dynamic Structures of Nucleic Acids --
|g 10.3.
|t Processes in the Central Dogma Affected by Dynamics of Nucleic Acid Structures --
|g 10.3.1.
|t Epigenetic Regulation Caused by Chemical Modification of DNA --
|g 10.3.2.
|t Co-transcriptional Formation of Metastable RNA Structures --
|g 10.3.3.
|t Co-transcriptional Translation and Transcription Attenuation --
|g 10.3.4.
|t Co-transcriptional Ligand Binding and Gene Regulation --
|g 10.3.5.
|t Translation Elongation and Co-translational Protein Folding --
|g 10.4.
|t Conclusion --
|t References --
|g 11.
|t Cancer And Nucleic Acid Structures --
|g 11.1.
|t Introduction --
|g 11.2.
|t Detail Mechanism of Cancer --
|g 11.2.1.
|t Cancer Incidence --
|g 11.2.2.
|t Relationship Between Genes and Cancer --
|g 11.3.
|t Non-canonical Structures of Nucleic Acids in Cancer Cells --
|g 11.3.1.
|t Structural Characteristics of Nucleic Acids in Cancer Cells --
|g 11.3.2.
|t Non-canonical Structures Perturb Gene Expression of Cancer-Related Genes --
|g 11.4.
|t Roles of Non-canonical Structures of Nucleic Acids in Cancer Cells --
|g 11.4.1.
|t Monitoring of Non-canonical Structures in Cancer Cells --
|g 11.4.2.
|t Regulation of Gene Expressions by the Non-canonical Structures in Cancer Cells --
|g 11.5.
|t Conclusion --
|t References --
|g 12.
|t Neurodegenerative Diseases And Nucleic Acid Structures --
|g 12.1.
|t Introduction --
|g 12.2.
|t Protein Aggregation-Induced Neurodegenerative Diseases --
|g 12.3.
|t DNA Shows Key Role for Neurodegenerative Diseases --
|g 12.4.
|t RNA Toxic Plays a Key Role for Neurological Diseases --
|g 12.5.
|t Conclusion --
|t References --
|g 13.
|t Therapeutic Applications --
|g 13.1.
|t Introduction --
|g 13.2.
|t Oligonucleotide Therapeutics --
|g 13.2.1.
|t Antisense Oligonucleotide --
|g 13.2.2.
|t Functions of Antisense Oligonucleotide Therapeutics --
|g 13.2.3.
|t Chemical Modifications in Therapeutic Oligonucleotides --
|g 13.2.3.1.
|t Backbone Modified Oligonucleotides --
|g 13.2.3.2.
|t Ribose Modified Oligonucleotides --
|g 13.2.3.3.
|t Oligonucleotides with Unnatural Backbone --
|g 13.2.4.
|t Oligonucleotide Therapeutics Other Than Antisense Oligonucleotide --
|g 13.2.4.1.
|t Oligonucleotide Therapeutics Functioning Through RNA Interference --
|g 13.2.4.2.
|t Oligonucleotide Therapeutics Functioning Through Binding to Protein --
|g 13.3.
|t Non-canonical Nucleic Acid Structures as Therapeutic Targets --
|g 13.3.1.
|t Traditional Antibiotics Targeting Structured Region of RNAs --
|g 13.3.2.
|t Strategies for Constructing Therapeutic Materials Targeting Structured Nucleic Acids --
|g 13.4.
|t Non-canonical Nucleic Acid Materials for Inducing Non-canonical Structures --
|g 13.5.
|t Conclusion --
|t References --
|g 14.
|t Materials Science And Nanotechnology Of Nucleic Acids --
|g 14.1.
|t Introduction --
|g 14.2.
|t Non-canonical Structure-Based Nanomaterials Resembling Protein Functions --
|g 14.2.1.
|t Aptamer --
|g 14.2.2.
|t DNAzyme --
|g 14.2.3.
|t Ion Channel --
|g 14.3.
|t Protein Engineering Using G4-Binding Protein --
|g 14.4.
|t Regulation of Gene Expression by G4-Inducing Materials --
|g 14.5.
|t Environmental Sensing --
|g 14.5.1.
|t Sensing Temperature in Cells --
|g 14.5.2.
|t Sensing pH in Cells --
|g 14.5.3.
|t Sensing K+ Ion in Cells --
|g 14.5.4.
|t Sensing Crowding Condition in Cells --
|g 14.6.
|t Conclusion --
|t References --
|
505 |
0 |
0 |
|a Contents note continued:
|g 15.
|t Future Outlook For Chemistry And Biology Of Non-Canonical Nucleic Acids --
|g 15.1.
|t Introduction --
|g 15.2.
|t Exploring Potential: Properties of Non-canonical Structures in Unusual Media --
|g 15.3.
|t Systemizing Properties: Prediction of the Formation of Non-canonical Nucleic Acids Structures --
|g 15.4.
|t Advancing Technology: Applications of Non-canonical Structures Taking Concurrent Reactions into Account --
|g 15.4.1.
|t Co-transcriptional Dynamics of G-Quadruplex --
|g 15.4.2.
|t Co-transcriptional Functionalization of Riboswitch-Like Sensor --
|g 15.4.3.
|t Co-transcriptional RNA Capturing for Selection of Functional RNAs --
|g 15.5.
|t Conclusion --
|t References.
|
533 |
|
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|a Electronic reproduction.
|b Ann Arbor, MI
|n Available via World Wide Web.
|
588 |
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|a Description based on online resource; title from digital title page (viewed on August 02, 2021).
|
650 |
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0 |
|a Nucleic acids.
|
650 |
|
0 |
|a Biochemistry.
|
710 |
2 |
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|a ProQuest (Firm)
|
776 |
0 |
8 |
|i Print version:
|a Sugimoto, N. (Naoki).
|t Chemistry and biology of non-canonical nucleic acids
|b First edition.
|d Hoboken : Wiley, 2020.
|z 9783527345212
|w (DLC) 2020024178
|
856 |
4 |
0 |
|u https://ebookcentral.proquest.com/lib/santaclara/detail.action?docID=6523041
|z Connect to this title online (unlimited simultaneous users allowed; 325 uses per year)
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