Chemistry and biology of non-canonical nucleic acids

Chemistry and biology of non-canonical nucleic acids /

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Bibliographic Details
Main Author: Sugimoto, N. (Naoki) (Author)
Corporate Author: ProQuest (Firm)
Format: Electronic eBook
Language:English
Published: Weinheim, Germany : Wiley-VCH, [2021]
Subjects:
Nucleic acids.
Biochemistry.
Online Access:Connect to this title online (unlimited simultaneous users allowed; 325 uses per year)

MARC

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100 1 |a Sugimoto, N.  |q (Naoki),  |e author. 
245 1 0 |a Chemistry and biology of non-canonical nucleic acids /  |c Naoki Sugimoto. 
264 1 |a Weinheim, Germany :  |b Wiley-VCH,  |c [2021] 
300 |a 1 online resource ( xii, 276 pages) :  |b illustrations (some color) 
336 |a text  |b txt  |2 rdacontent 
337 |a computer  |b n  |2 rdamedia 
338 |a online resource  |b nc  |2 rdacarrier 
504 |a Includes bibliographical references and index. 
505 0 0 |a Machine generated contents note:   |g 1.  |t History For Canonical And Non-Canonical Structures Of Nucleic Acids --   |g 1.1.  |t Introduction --   |g 1.2.  |t History of Duplex --   |g 1.3.  |t Non-Watson--Crick Base Pair --   |g 1.4.  |t Nucleic Acid Structures Including Non-Watson--Crick Base Pairs --   |g 1.5.  |t Perspective of the Research for Non-canonical Nucleic Acid Structures --   |g 1.6.  |t Conclusion and Perspective --   |t References --   |g 2.  |t Structures Of Nucleic Acids Now --   |g 2.1.  |t Introduction --   |g 2.2.  |t Unusual Base Pairs in a Duplex --   |g 2.2.1.  |t Hoogsteen Base Pair --   |g 2.2.2.  |t Purine--Pyrimidine Mismatches --   |g 2.2.3.  |t Purine--Purine Mismatches --   |g 2.2.4.  |t Pyrimidine--Pyrimidine Mismatches --   |g 2.3.  |t Non-canonical Backbone Shapes in DNA Duplex --   |g 2.4.  |t Branched DNA with Junction --   |g 2.5.  |t Multi-stranded DNA Helices --   |g 2.6.  |t Structures in RNA --   |g 2.6.1.  |t Basic Structure Distinctions of RNA --   |g 2.6.2.  |t Elements in RNA Secondary Structures --   |g 2.6.2.1.  |t Hairpin Loop --   |g 2.6.2.2.  |t Bulge Loop --   |g 2.6.2.3.  |t Internal Loop --   |g 2.6.3.  |t Elements in Tertiary Interactions of RNA --   |g 2.6.3.1.  |t A-Minor Interactions --   |g 2.6.3.2.  |t Ribose Zipper --   |g 2.6.3.3.  |t T-Loop Motif --   |g 2.6.3.4.  |t Kissing-Loop Interaction --   |g 2.6.3.5.  |t GNRA Tetraloop Receptor Interaction --   |g 2.6.3.6.  |t Pseudoknot Crosslinking Distant Stem Regions --   |g 2.7.  |t Conclusion --   |t References --   |g 3.  |t Stability Of Non-Canonical Nucleic Acids --   |g 3.1.  |t Introduction --   |g 3.2.  |t Factors Influencing Stabilities of the Canonical Duplexes --   |g 3.2.1.  |t Hydrogen Bond Formations --   |g 3.2.2.  |t Stacking Interactions --   |g 3.2.3.  |t Conformational Entropy --   |g 3.3.  |t Thermodynamic Analysis for the Formation of Duplex --   |g 3.4.  |t Factors Influencing Stabilities of the Non-canonical Nucleic Acids --   |g 3.4.1.  |t Factors Influencing Stability of Triplexes --   |g 3.4.2.  |t Factors Influencing Stability of Quadruplex --   |g 3.4.2.1.  |t G-Quadruplexes --   |g 3.4.2.2.  |t i-Motif --   |g 3.5.  |t Thermodynamic Analysis for the Non-canonical Nucleic Acids --   |g 3.5.1.  |t Thermodynamic Analysis for the Intramolecular Triplex and Tetraplex --   |g 3.5.2.  |t Thermodynamic Analysis for the Intermolecular Triplex --   |g 3.5.3.  |t Thermodynamic Analysis for the Tetraplex --   |g 3.6.  |t Conclusion --   |t References --   |g 4.  |t Physicochemical Properties Of Non-Canonical Nucleic Acids --   |g 4.1.  |t Introduction --   |g 4.2.  |t Spectroscopic Properties of Non-canonical Nucleic Acids --   |g 4.2.1.  |t Effect of Non-canonical Structure on UV Absorption --   |g 4.2.2.  |t Circular Dichroism of Non-canonical Nucleic Acids --   |g 4.2.3.  |t NMR Spectroscopy --   |g 4.2.4.  |t Other Spectroscopic Characteristics of Non-canonical Nucleic Acids --   |g 4.3.  |t Chemical Interactions on Non-canonical Nucleic Acids --   |g 4.3.1.  |t Hydration --   |g 4.3.2.  |t Cation Binding --   |g 4.3.3.  |t pH Effect --   |g 4.3.4.  |t Chemical Modification --   |g 4.4.  |t Chemical Platform on the Non-canonical Structures --   |g 4.4.1.  |t Specificity of a Ligand to Non-canonical Structures --   |g 4.4.2.  |t Fluorescence Platform of Non-canonical Structures --   |g 4.4.3.  |t Interface Between Proteins and Nucleic Acids --   |g 4.5.  |t Physicochemical Property of Non-canonical Nucleic Acids in Cell --   |g 4.5.1.  |t Molecular Crowding Condition that Reflects Cellular Environments --   |g 4.5.2.  |t Effects of Crowding Reagents on Non-canonical Nucleic Acid Structures --   |g 4.5.3.  |t Quantification of Physical Properties of Non-canonical Structures in Crowding Condition --   |g 4.5.4.  |t Non-canonical Structures Under Mimicking Organelle Environment --   |g 4.5.5.  |t Insight for the Formation of Non-canonical Nucleic Acids in Cells --   |g 4.6.  |t Conclusion --   |t References --   |g 5.  |t Telomere --   |g 5.1.  |t Introduction --   |g 5.2.  |t Structural Properties of Telomere --   |g 5.2.1.  |t Structures of Telomere --   |g 5.2.2.  |t Structural Properties of Human Telomeric G4s --   |g 5.2.3.  |t Structure of Repeats of Human Telomeric G4s --   |g 5.3.  |t Biological Relevance of Telomere G4 --   |g 5.3.1.  |t Telomerase Activity --   |g 5.3.2.  |t Telomerase Repeated Amplification Protocol (TRAP) Assay --   |g 5.3.3.  |t Alternative Lengthening of Telomere (ALT) Mechanism --   |g 5.4.  |t Other Non-canonical Structures Related to Telomere Region --   |g 5.4.1.  |t Telomere i-Motif --   |g 5.4.2.  |t Telomere RNA --   |g 5.5.  |t Conclusion --   |t References --   |g 6.  |t Transcription --   |g 6.1.  |t Introduction --   |g 6.2.  |t Transcription Process --   |g 6.2.1.  |t Transcription Initiation --   |g 6.2.2.  |t Transcription Elongation --   |g 6.2.3.  |t Transcription Termination --   |g 6.3.  |t Transcription Process Perturbed by Certain Sequences of DNA and RNA --   |g 6.4.  |t Transcription Process Perturbed by Non-canonical Structures of DNA and RNA --   |g 6.5.  |t Conclusion --   |t References --   |g 7.  |t Translation --   |g 7.1.  |t Introduction --   |g 7.2.  |t RNAs Involved in Translation Machinery --   |g 7.3.  |t General Process of Translation --   |g 7.3.1.  |t Translation Initiation --   |g 7.3.2.  |t Translation Elongation --   |g 7.3.3.  |t Translation Termination --   |g 7.4.  |t RNA Structures Affecting Translation Reaction --   |g 7.4.1.  |t Modulation of Translation Initiation in Prokaryotes --   |g 7.4.2.  |t Modulation of Translation Initiation in Eukaryotes --   |g 7.4.3.  |t RNA Structures Affecting Translation Elongation --   |g 7.4.4.  |t RNA Structures Affecting Translation Termination --   |g 7.5.  |t Conclusion --   |t References --   |g 8.  |t Replication --   |g 8.1.  |t Introduction --   |g 8.2.  |t Replication Machineries --   |g 8.3.  |t Replication Initiation --   |g 8.3.1.  |t Mechanism of Activation of Replication Origins --   |g 8.3.2.  |t Activation Control of Origins by G4s --   |g 8.3.3.  |t Control of Timing of Replication Initiation by G4s --   |g 8.4.  |t DNA Strand Elongation --   |g 8.4.1.  |t Mechanism of DNA Strand Elongation --   |g 8.4.2.  |t Impact of G4 and i-Motif Formations on DNA Strand Synthesis --   |g 8.4.3.  |t Relationship Between G4 and Epigenetic Modification --   |g 8.4.4.  |t Expansion and Contraction of Replicating Strand Induced by Hairpin Structures --   |g 8.5.  |t Termination of Replication --   |g 8.6.  |t Chemistry of the Replication and Its Regulation --   |g 8.6.1.  |t Cellular Environments --   |g 8.6.2.  |t Control of Replication by Chemical Compounds --   |g 8.7.  |t Conclusion --   |t References --   |g 9.  |t Helicase --   |g 9.1.  |t Introduction --   |g 9.2.  |t Function and Structure of Helicases --   |g 9.3.  |t Unwinding of Non-canonical DNA Structures by Helicases --   |g 9.4.  |t G4 Helicases in Gene Expressions --   |g 9.5.  |t G4 Helicases in Replication --   |g 9.6.  |t G4 Helicases in Telomere Maintenance --   |g 9.7.  |t Relation to Diseases by Loss of G4 Helicases --   |g 9.8.  |t Insight into Specific Properties of Activities of G4 Helicase Under Cellular Conditions --   |g 9.9.  |t Conclusion --   |t References --   |g 10.  |t Dynamic Regulation Of Biosystems By Nucleic Acids With Non-Canonical Structures --   |g 10.1.  |t Introduction --   |g 10.2.  |t Time Scale of Biological Reactions --   |g 10.2.1.  |t Cell Cycle --   |g 10.2.2.  |t Central Dogma --   |g 10.2.3.  |t Dynamic Structures of Nucleic Acids --   |g 10.3.  |t Processes in the Central Dogma Affected by Dynamics of Nucleic Acid Structures --   |g 10.3.1.  |t Epigenetic Regulation Caused by Chemical Modification of DNA --   |g 10.3.2.  |t Co-transcriptional Formation of Metastable RNA Structures --   |g 10.3.3.  |t Co-transcriptional Translation and Transcription Attenuation --   |g 10.3.4.  |t Co-transcriptional Ligand Binding and Gene Regulation --   |g 10.3.5.  |t Translation Elongation and Co-translational Protein Folding --   |g 10.4.  |t Conclusion --   |t References --   |g 11.  |t Cancer And Nucleic Acid Structures --   |g 11.1.  |t Introduction --   |g 11.2.  |t Detail Mechanism of Cancer --   |g 11.2.1.  |t Cancer Incidence --   |g 11.2.2.  |t Relationship Between Genes and Cancer --   |g 11.3.  |t Non-canonical Structures of Nucleic Acids in Cancer Cells --   |g 11.3.1.  |t Structural Characteristics of Nucleic Acids in Cancer Cells --   |g 11.3.2.  |t Non-canonical Structures Perturb Gene Expression of Cancer-Related Genes --   |g 11.4.  |t Roles of Non-canonical Structures of Nucleic Acids in Cancer Cells --   |g 11.4.1.  |t Monitoring of Non-canonical Structures in Cancer Cells --   |g 11.4.2.  |t Regulation of Gene Expressions by the Non-canonical Structures in Cancer Cells --   |g 11.5.  |t Conclusion --   |t References --   |g 12.  |t Neurodegenerative Diseases And Nucleic Acid Structures --   |g 12.1.  |t Introduction --   |g 12.2.  |t Protein Aggregation-Induced Neurodegenerative Diseases --   |g 12.3.  |t DNA Shows Key Role for Neurodegenerative Diseases --   |g 12.4.  |t RNA Toxic Plays a Key Role for Neurological Diseases --   |g 12.5.  |t Conclusion --   |t References --   |g 13.  |t Therapeutic Applications --   |g 13.1.  |t Introduction --   |g 13.2.  |t Oligonucleotide Therapeutics --   |g 13.2.1.  |t Antisense Oligonucleotide --   |g 13.2.2.  |t Functions of Antisense Oligonucleotide Therapeutics --   |g 13.2.3.  |t Chemical Modifications in Therapeutic Oligonucleotides --   |g 13.2.3.1.  |t Backbone Modified Oligonucleotides --   |g 13.2.3.2.  |t Ribose Modified Oligonucleotides --   |g 13.2.3.3.  |t Oligonucleotides with Unnatural Backbone --   |g 13.2.4.  |t Oligonucleotide Therapeutics Other Than Antisense Oligonucleotide --   |g 13.2.4.1.  |t Oligonucleotide Therapeutics Functioning Through RNA Interference --   |g 13.2.4.2.  |t Oligonucleotide Therapeutics Functioning Through Binding to Protein --   |g 13.3.  |t Non-canonical Nucleic Acid Structures as Therapeutic Targets --   |g 13.3.1.  |t Traditional Antibiotics Targeting Structured Region of RNAs --   |g 13.3.2.  |t Strategies for Constructing Therapeutic Materials Targeting Structured Nucleic Acids --   |g 13.4.  |t Non-canonical Nucleic Acid Materials for Inducing Non-canonical Structures --   |g 13.5.  |t Conclusion --   |t References --   |g 14.  |t Materials Science And Nanotechnology Of Nucleic Acids --   |g 14.1.  |t Introduction --   |g 14.2.  |t Non-canonical Structure-Based Nanomaterials Resembling Protein Functions --   |g 14.2.1.  |t Aptamer --   |g 14.2.2.  |t DNAzyme --   |g 14.2.3.  |t Ion Channel --   |g 14.3.  |t Protein Engineering Using G4-Binding Protein --   |g 14.4.  |t Regulation of Gene Expression by G4-Inducing Materials --   |g 14.5.  |t Environmental Sensing --   |g 14.5.1.  |t Sensing Temperature in Cells --   |g 14.5.2.  |t Sensing pH in Cells --   |g 14.5.3.  |t Sensing K+ Ion in Cells --   |g 14.5.4.  |t Sensing Crowding Condition in Cells --   |g 14.6.  |t Conclusion --   |t References -- 
505 0 0 |a Contents note continued:   |g 15.  |t Future Outlook For Chemistry And Biology Of Non-Canonical Nucleic Acids --   |g 15.1.  |t Introduction --   |g 15.2.  |t Exploring Potential: Properties of Non-canonical Structures in Unusual Media --   |g 15.3.  |t Systemizing Properties: Prediction of the Formation of Non-canonical Nucleic Acids Structures --   |g 15.4.  |t Advancing Technology: Applications of Non-canonical Structures Taking Concurrent Reactions into Account --   |g 15.4.1.  |t Co-transcriptional Dynamics of G-Quadruplex --   |g 15.4.2.  |t Co-transcriptional Functionalization of Riboswitch-Like Sensor --   |g 15.4.3.  |t Co-transcriptional RNA Capturing for Selection of Functional RNAs --   |g 15.5.  |t Conclusion --   |t References. 
533 |a Electronic reproduction.  |b Ann Arbor, MI  |n Available via World Wide Web. 
588 |a Description based on online resource; title from digital title page (viewed on August 02, 2021). 
650 0 |a Nucleic acids. 
650 0 |a Biochemistry. 
710 2 |a ProQuest (Firm) 
776 0 8 |i Print version:  |a Sugimoto, N. (Naoki).  |t Chemistry and biology of non-canonical nucleic acids  |b First edition.  |d Hoboken : Wiley, 2020.  |z 9783527345212  |w (DLC) 2020024178 
856 4 0 |u https://ebookcentral.proquest.com/lib/santaclara/detail.action?docID=6523041  |z Connect to this title online (unlimited simultaneous users allowed; 325 uses per year)  |t 0 
907 |a .b38101488  |b 210823  |c 210823 
998 |a uww  |b    |c m  |d z   |e l  |f eng  |g gw   |h 0 
917 |a GOBI ProQuest DDA 
919 |a .ulebk  |b 2020-07-09 
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