Continuous pharmaceutical processing
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| Corporate Author: | |
|---|---|
| Other Authors: | , , |
| Format: | Electronic eBook |
| Language: | English |
| Published: |
Cham :
Springer,
2020.
|
| Series: | AAPS advances in the pharmaceutical sciences series ;
v. 42. |
| Subjects: | |
| Online Access: | Connect to this title online (unlimited simultaneous users allowed; 325 uses per year) |
Table of Contents:
- Intro
- Preface
- Contents
- Chapter 1: Basic Principles of Continuous Manufacturing
- 1.1 Introduction
- 1.2 General Characteristics of Continuous Processes
- 1.3 Multiunit Continuous Processes
- 1.4 Requirements for Effective Continuous Processing
- 1.5 Comparative Assessment of Batch and Continuous Operating Modes
- References
- Chapter 2: Continuous Reactors for Pharmaceutical Manufacturing
- 2.1 Introduction
- 2.2 Superheated PFR in Oven for Imidazole Cyclization
- 2.3 Pulsating Flow Coiled Tube PFR for Hydroformylation with Solids Precipitate
- 2.4 Vertical Pipes-in-Series PFR for Reductive Amination
- 2.5 Superheated PFR in Steam Shell for Thermal EE Deprotection
- 2.6 CSTRs-in-Series for Schotten-Baumann with Two Liquid Phases
- 2.7 Intermittent Flow Stirred Tank Reactor for Suzuki Cross-Coupling with Two Liquid Phases
- 2.8 CSTRs-in-Series for Barbier Grignard, Quench, and Neutralization to Minimize Racemization
- 2.9 Low-Pressure Disposable Coiled Tube PFR for Highly Potent Compound
- 2.10 Understanding the Real Reaction Temperature in a PFR
- References
- Chapter 3: Understanding Residence Time, Residence Time Distribution, and Impact of Surge Vessels
- 3.1 Residence Time Distribution in PFRs Is a Consequence of Axial Dispersion
- 3.2 Advantages and Disadvantages of Low Axial Dispersion
- 3.3 Quantifying Axial Dispersion in Plug Flow Tube Reactors
- 3.4 Quantifying Impact of Axial Dispersion on Reactor Performance
- 3.5 Axial Dispersion in PFRs Dampens Out Flow Disturbances
- 3.6 Importance of High L/d When Scaling Up in the Laminar Flow Regime
- 3.7 Calculated Peclet Number Does Not Correlate Well with Measured Axial Dispersion
- 4.1.1 Slurry Flow Out of Continuous Stirred Tank Crystallizers
- 4.1.2 Filtration Downstream from Continuous Crystallization
- 4.1.3 Solvent Exchange Distillation with Strip to Dryness in Rotary Evaporators
- 4.1.4 Back Pressure Regulators and Vapor-Liquid Separators Downstream from Continuous High-Pressure Hydrogenation Reactors
- 4.1.5 Stirred Tank Reactors for Heterogeneous Reactions
- 4.2 Recycle
- 4.3 Common Misconception About Needing Fast Reactions in PFRs
- 4.4 Continuous Process Checklist
- References
- Chapter 5: Continuous Crystallization: Equipment and Operation