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Table of Contents: “…Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease -- Introduction: Heat Shock Proteins—From Drosophila Stress Proteins to Mediators of Human Disease -- Stress Response and Molecular Chaperones -- Biology of the Heat Shock Response and Stress Conditioning -- Bacterial Stress Sensors -- Unfolded Protein Response: Contributions to Development and Disease -- Molecular Mechanisms of Stress Protein Expression -- Genetic Models of HSF Function -- HSF1 and HSP Gene Regulation -- Cellular Stress Proteins -- Small Heat Shock Proteins in Physiological and Stress-Related Processes -- Large Mammalian hsp70 Family Proteins, hsp110 and grp170, and Their Roles in Biology and Cancer Therapy -- Molecular Chaperones and Protein Folding -- Regulation of Hsp70 Function: Hsp40 Co-Chaperones and Nucleotide Exchange Factors -- Protein Disassembly by Hsp40-Hsp70 -- Mammalian HSP40/DnaJ Chaperone Proteins in Cytosol -- Role of Molecular Chaperones in Cell Regulation -- FKBP Co-Chaperones in Steroid Receptor Complexes -- Up and Down Regulation of the Stress Response by the Co-Chaperone Ubiquitin Ligase CHIP -- Role of Cdc37 in Protein Kinase Folding -- Intracellular and Extracellular Stress Proteins in Human Disease -- Targeting Hsp90 in Cancer and Neurodegenerative Disease -- gp96 and Tumor Immunity -- Immunoregulatory Activities of Extracellular Stress Proteins -- Heat Shock Proteins and Neurodegenerative Diseases -- Heat Shock Proteins in the Progression of Cancer.…”
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Table of Contents: “…Advantages of Considering Gene Regulation in Genome-Scale Modeling --…”
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Table of Contents: “…Part I Bioinformatics and Other Methodologies for lncRNAs -- 1 Complexity of Mammalian Transcriptome Analyzed by RNA Deep Sequencing -- 2 Synthetic Strategies to Identify and Regulate Noncoding RNAs -- Part II Atomic and Molecular Structures of lncRNAs -- 3 Structure and Interaction with Protein of Noncoding RNA: A Case for an RNA Aptamer Against Prion Protein -- 4 Characterization of G-quadruplex DNA- and RNA-binding Protein -- Part III Molecular Functions of lncRNAs -- 5 Initiation of Transcription Generates Divergence of Long Noncoding RNAs -- 6 Beneath the Veil of Biological Complexity There Lies Long Noncoding RNA: Diverse Utilization of lncRNA in Yeast Genomes -- 7 Long Noncoding RNAs as Structural and Functional Components of Nuclear Bodies -- Part IV Biological Actions of lncRNAs -- 8 Long Noncoding RNA in Epigenetic Gene Regulation -- 9 Mechanisms of Long Noncoding Xist RNA-mediated Chromosome-wide Gene Silencing in X-chromosome Inactivation -- Part V Potential Outcomes for Clinical Medicine -- 10 Regulation of pRB and p53 Pathways by Long Noncoding RNAs, ANRIL, lincRNA-p21, lincRNA-RoR and PANDA -- 11 The Role of Androgen-regulated Long Noncoding RNAs in Prostate Cancer -- 12 Macrophage Activation as a Model System for Understanding Enhancer Transcription and eRNA Function -- 13 Long Noncoding RNA Functions as a Regulator for Steroid Hormone Receptors Related Breast and Prostate Cancers -- BM Index.…”
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Table of Contents: “…Activity-regulated Transcription: Getting to the Nucleus -- Transcriptional Regulation of Activity-Dependent Genes by Birdsong -- To the Nucleus with Proteomics -- Transcriptional Regulation of the Tbr1-CASK-CINAP Protein Complex in Response to Neuronal Activity -- Intracellular Calcium Waves Transmit Synaptic Information to the Nucleus in Hippocampal Pyramidal Neurons -- Role of Action Potentials in Regulating Gene Transcription: Relevance to LTP -- L-type Channel Regulation of Gene Expression -- Activity-regulated Transcription: Gene Regulation -- CREB-Dependent Transcription and Synaptic Plasticity -- Activity-Dependent Regulation of Brain-derived neurotrophic factor Transcription -- Role of Signal-responsive Class IIa Histone Deacetylases in Regulating Neuronal Activity-dependent Gene Expression -- NFAT-Dependent Gene Expression in the Nervous System: A Critical Mediator of Neurotrophin-Induced Plasticity -- Activity-Dependent Bigenomic Transcriptional Regulation of Cytochrome c Oxidase in Neurons -- Not Just for Muscle Anymore: Activity and Calcium Regulation of MEF2-Dependent Transcription in Neuronal Survival and Differentiation -- Activity-regulated Transcription: Role in Nervous System Function -- Synaptic Growth and Transcriptional Regulation in Drosophila -- MMP-9/TIMP-1 Extracellular Proteolytic System as AP-1 Target in Response to Neuronal Activity -- Activity-dependent Gene Transcription in Neurons: Defining the Plasticity Transcriptome -- Transcriptional Mechanisms Underlying the Mammalian Circadian Clock -- Intersecting Genetics with Lifestyle: the Role of Exercise and Diet in Synaptic Plasticity and Cognitive Enhancement -- CREB Responsive Transcription and Memory Formation -- Dynamic Transcription of the Immediate-Early Gene Arc in Hippocampal Neuronal Networks: Insights into the Molecular and Cellular Bases of Memory Formation.…”
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Table of Contents: “…-Drug Addiction and Histone Code Alterations -- Anxiety and Epigenetics -- Part III: Brain Disorders During Adulthood -- Histone Modifications in Major Depressive Disorder and Related Rodent Models -- DNA Methylation in Major Depressive Disorder -- Non-Coding RNAs in Depression -- DNA Methtlation in Schizophrenia -- Histone Post-translational Modifications in Schizophrenia -- Epigenetic Mechanisms of Gene Regulation in Amyotrophic Lateral Sclerosis (ALS) -- Epigenetics of Huntington’s Disease -- Part IV: Elderly Disorders.…”
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Table of Contents: “…The Use of Immediate Early Genes as Mapping Tools for Neuronal Activation: Concepts and Methods -- The Use of Immediate Early Genes as Mapping Tools for Neuronal Activation: Concepts and Methods -- Immediate Early Gene Expression as Part of Sensory Processing -- Regulation of Immediate Early Genes in the Visual Cortex -- Immediate Early Gene Regulation in the Auditory System -- Immediate Early Genes and Sensory Maps of Olfactory and Gustatory Function -- Immediate Early Gene Expression in the Primary Somatosensory Cortex: Focus on the Barrel Cortex -- Immediate Early Genes Induced in Models of Acute and Chronic Pain -- Immediate Early Gene Expression in Complex Systems and Higher Order Cognitive Function -- Mapping Sleep-Wake Control with the Transcription Factor c-Fos -- c-Fos and Zif268 in Learning and Memory—Studies on Expression and Function -- Immediate Early Genes and the Mapping of Environmental Representations in Hippocampal Neural Networks -- Neuronal Dysfunction and Cognitive Impairment Resulting from Inactivation of the Egr-Family Transcription Factor zif268 -- Immediate Early Genes in Neurological Disorder: Clinical Implications -- The Contribution of Immediate Early Genes to the Understanding of Brain Processing of Stressors -- Transcriptional Control of Nerve Cell Death, Survival and Repair -- Immediate Early Genes, Inducible Transcription Factors and Stress Kinases in Alzheimer’s Disease -- Parkinson’s Disease, the Dopamine System and Immediate Early Genes.…”
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Table of Contents: “…PART I -- Foreword -- Extreme Observations in Biomedical Data -- An Ordinal Joint Model for Breast Cancer -- Sample Size Impact on the Categorisation of Continuous Variables in Clinical Prediction -- ntegrative Analysis of Transcriptomics and Proteomics Data for the Characterization of Brain Tissue After Ischemic Stroke -- Applying INAR-Hidden Markov Chains in the Analysis of Under-Reported Data -- Joint Modelling for Flexible Multivariate Longitudinal and Survival Data: Application in Orthotopic Liver Transplantation -- A Multi-State Model for the Progression to Osteopenia and Osteoporosis among HIV-Infected Patients -- Statistical Challenges for Human Microbiome Analysis -- Integrative Analysis to Select Genes Regulated by Methylation in a Cancer Colon Study -- Topological Pathway Enrichment Analysis of Gene Expression in High Grade Serous Ovarian Cancer Reveals Tumor-Stoma Cross-Talk -- PART II -- Foreword -- Biological Dosimetry, Statistical Challenges: Biological Dosimetry after High-Dose Exposures to Ionizing Radiation -- Heterogeneous Correlation of Multi-Level Omics Data for the Consideration of Inter-Tumoural Heterogeneity -- Overview of Topics Related to Model Selection for Regression -- Understanding Plaque Overlap is Essential for Modelling Radiation Induced Atherosclerosis -- On the Use of Random Effect Models for Radiation Biodosimetry -- Modelling of the Radiation Carcinogenesis: the Analytic and Stochastic Approaches -- Bayesian Solutions to Biodosimetry Count Data Problems and Supporting Software -- Empirical Assessment of Gene Expression Biomarkers for Radiation Exposure -- Poisson-Weighted Estimation by Discrete Kernel with Application to Radiation Biodosimetry -- R Implementation of the Excess Relative Rate Model: Applications to Radiation Epidemiology -- Uncertainty Considerations Following a Mechanistic Analysis of Lung Cancer Mortality.…”
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